SAVER (Single-cell Analysis Via Expression Recovery) implements a regularized regression prediction and empirical Bayes method to recover the true gene expression profile in noisy and sparse single-cell RNA-seq data.

You can install SAVER from CRAN by running:

install.packages("SAVER")
library(SAVER)

You can also install the most recent updates of SAVER from github with:

# install.packages("devtools")
devtools::install_github("mohuangx/SAVER")

For more information about the method, check out the website, tutorial, and paper.