1. Font++; and fix some GUI errors;
2. Add some functions in `getORF`;
3. Fix an error in `getORF`;
4. Re-design `DNA2AA` (including Translate,getORF,trimSeqEnding); 
5. ==========================================
    1. Improve the `getORF` efficiency in dealing with large file;
2. Allow manually input IDs for Concatenating seqs in `Merge`;
3. Improve the `GenBank` functions to read/write/extract gb files;
4. Re-cluster functions & Resize every module GUI;
5. Add and Improve `Seq` module for comparing two sequences;
6. Improve `NCBI Blast` & `NCBI Entrez` module;
7. Add `CMP2Align-Batch` function in `Align module`;
8. Fix some small GUI errors;
9. Fix one small error in genbank parser when //product name occurr multiple times; (20230516) 

1. Improve the `Trim` function in effciency and speed;
2. Improve the `Editor` function by adding 'Rename ID' and 'Add another file';
3. Fix some UI errors in `Editor`;
4. Code optimization for initialization

1. improve the `Segregating site detection` methods in `Align`;
2. add `MACSE` alignment construction for codon sequences in `Align`;
3. add `Gblocks` and `MACSE` trimming functions in `Align`;
4. add `Batch entrez` function (beta) in `NCBI`;
5. change some UI;
6. improve the `CMP2Seq` functions and fix several bugs;
7. Move the `manually compare 2 seqs` to a single Window;
8. improve `Editor` by changing the viewing interface
9. add the `Haplotype` function in `Editor`;
10. improve the Menu list in `Editor`
11. improve the identification of Segregating sites in `Align` again
12. improve the length calculation in 'Align' (without N and Gap)
13. add file size estimation before openning it by `Editor`
14. add auto rename long IDs in Fasta files in module `ID`
15. add Text input interface in new `Editor`

1. UI improvement;
2. fix an error in `AA2DNA` function when cDNA is used;
3. Improve running process information display in `Filter`；
4. Improve the `Trim` function by adding a parameter `Min out block length`;
5. Improve the running information display in `Trim`;
6. Improve the `Trim` function by integrating Codon-Substitution Matrix;
7. Fix an error in `Trim` function when there is no low-quality column;
8. add a `Random` funtion to insert random sequences into alignments;
9. add an option of Pseudogenes identification in `DNA2AA`;
10. add an option of length-filtration in `Filter` -> `Length`;
11. add icons to buttons (2019-4-16);
12. Improve Mitochondrial GenBank Parser in some details.
13. Improve `Sort` function when dealing with repeated IDs.
14. Back to the older version (v4.5) of PAML
15. add removation based on keywords (`Filter-Keyword`)
16. add extraction based on multiple regions for alignments (eg. 10-300,400-1000)

1. Improve the `Blast` function by saving and viewing subject seqs;
2. Improve the length calculation in `Align`;
3. add the MAFFT-Fast option (for large data sets) in `Align`;
4. Improve running process displaying in both `Align` and `Filter`;
5. fix some UI errors (20181130)
6. fix an error in `Sort` when same IDs are present in one file;
7. change the default ID list to all non-redundant IDs in `Merge`;
8. add tree rename function in `TreeTools`;
9. move `Blast` to module `NCBI`, and changed to `NCBI Local Blast`;
10. add `GenBank File Parser` into `NCBI` (for mitochondrial genome);
11. fix an UI error in `AA2DNA`(codon alignment guided by amino-acid alignment);
12. change the file size cutoff to 50 Mb (instead of 30 Mb);
13. add a FlatUI skin to the main program.

1. add `Blast` function (at below tool-bar);
2. add `Filter` by hyplotype;
3. Improve the alignment coloring in Phylip format (in `Editor`);
4. speeding up the `GeneDrawer` with gene-exon sequences;
5. add `Get non-redundant IDs for multiple files` in `ID` module;
6. improve the usability under Win10 operating system;
7. Improve the Blast result viewing function;
8. Improve the right-click interface for `Align` and `Filter`;
9. change several UI;
10. Fix an error in estimating the Alignment Similarity.
11. add Kalign method in `Align` (fast for large data sets) 
12. Improve the `Primer` module (adding manually running mode)

1. add Find all and Replace functions in `Editor`;
2. improve the `AA2DNA` to allow back-translate from trimmed AA alignments [beta];
3. improve the `CMP2Seq` in manual mode by performing Muscle alignment;
4. add some more example files in the work folder;
5. fix small errors in GUI;
6. fix one fetal error in `Merge` (this error is not present in older versions);
7. add the sequence length calculation function in `Align`
8. fix small errors in `Editor`; (2018-7-25)
9. add Recursively removing bad sequences in `Filter::Length` function;
10. automated adding GAPs in `Merge` when seq not found;
11. add file transfer function in each module;
12. add coloring function for the conservative regions with Phylip format;
13. add CMD display interface to `Align` and `PAML`; (2018-8-7)
14. improve the `Trim` function to deal with uncertain bases;
15. improve the coloring function in `Editor`;

1. add aligner parameter setting function;
2. fix an important error in `Primer` design; (2018-3-21)
3. optimized some codes for running on Windows 10; (2018-3-21)
4. edit the citation display (2018-3-22)
5. change the width of main window for good display in some pc (2018-3-27)
6. improve the `Sim` function (2018-3-30)
7. improve the UI display under high DPI (maybe not stable) (2018-3-30)
8. improve the `Trim` function with better output display (2018-4-8)
9. add 'auto_check_update' function when start up the program (2018-4-8)

1. add `AA2DNA` to obtain codon alignments based on aa alignments;
2. change all buttons 'Scan' to 'Open'; (2018-2-5)
3. add result display as well as result viewing function by double click;
4. add 'Delete' operation on selected files 
(useful for transforming one function's outputs to another function's inputs)
5. add automated gap-deletion in template DNA for primer design;
6. Clear the primer results when starting a new primer design; (2018-2-5)
7. active the scroll bar in the `Align` window;
8. improve ID preview function for `Filter`;
9. optimized codes, especially for `CMP2Seq`(2018-2-5)
10.fix a little GUI errors in `CMP2Seq` (2018-2-7)
11.improve the result display for `CMP2Align` (2018-2-7)
12.fix a small error in selecting files in `AA2DNA` (2018-2-11)
13.change file extension to '.fasta' in default; (2018-2-27)
14.improve the result viewing function (when no viewing tool installed); (2018-2-27)
15.optimize codes, , especially for `Editor` (2018-2-28 & 2018-3-8)

1. improve interface display
2. move the `classification` function to `Filter` (Based on keywords)
3. add drag-function to selecte files into the list box [2018-1-11]
4. fix errors in selecting files when there have been files in the listbox [2018-1-11]
5. add new auto-update function [2018-1-11]
6. greatly improve the `Sort & Rename` function for easy to use [2018-1-15]
7. fix UI (radiobutton) errors in `Merge` [2018-1-15]
8. fix errors in filtration based on keywords [2018-1-15]
9. improve update checking function [2018-1-15]
10.add folder-drag function to selecte multiple files [2018-1-15]

1. fix errors in `Filter` based on length;
2. improve usability of `Filter` based on similarity
3. improve global settings (tmp folder, associate suffix...)
4. add 'Merge' and 'Concatenate' functions in `Merge` function
5. improve `Sort` functions; change rename IDs by setting '=>'
6. auto fresh the view of 2 sequences after align
7. add deleting empty columns ("-" for all seqs) in alignments (20171217)
8. improve similarity estimate by considering RevCmp seq in `Filter` (20171217) 
9. improve `Filter` function based on similarity (20171218)
10. improve similarity estimate by considering indels (for `AlignSim` and `Filter`) (20171218)
11. improve `Filter` function based on ID (showing more result information; 20171220)
12. improve `Filter` function based on similarity when input sequences too long (20171221)
13. edit the user guide (20171225)
14. fix bugs of closing window when it is running (20171226)
15. improve `Filter` function based on IDs to show more running process information (20171226)
16. remove the symbol "'" in nexus output of `Format` (20180104);
17. fix errors in `Sort` when ">" present in ID (20180109)

1. add filtration based on similarity
2. optimize codes for AlignTrim
3. improve classification function

1. Redesign the GUI
2. Add Text Editor for FasParser
3. Add GeneStructre drawer function
4. Add AlignTrim & AlignScore functions
5. Add batch sort & classification function
6. Add Primer designning function (with Primer3)
7. Add Positive selection detection (with PAML)
8. Add Bug report function